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MOTS-c, The Mitochondrial-Derived Peptide is a peptide of 16 amino acids expressed by a mitochondrial gene. Popularly known as the “Powerhouse of the cell,” mitochondria play a key role in signalling and energy production. Studies include MOTS-c peptide’s influence on lifespan and longevity, exercise capacity, metabolism and weight regulation, and processes leading to disease states such as osteoporosis. MOTS-c is identified as a natural peptide as researchers found it in cell nuclei and in general circulation.
MOTS-c peptide has been shown to:
Helps regulate mitochondrial energy
Promotes resistance to metabolic stress
Improves exercise capacity
Helps prevent osteoporosis
Improves glucose regulation
Reduces obesity
Reduces insulin resistance
Promotes fatty acid metabolism in the liver
Promotes metabolic flexibility and homeostasis
This product is prepared for RESEARCH USE ONLY and may not be used for other purposes.
MOTS-c is believed to improve mitochondrial function by activating the AMP-activated protein kinase (AMPK) pathway. AMPK was identified in 1999 as the master switch for metabolism and the central regulator of both glucose and lipid (fat) metabolism. When activated, AMPK helps to increase glucose uptake and fatty acid oxidation, which can lead to improved energy production and metabolic function. Since then it has been a target for therapeutic intervention against metabolic conditions such as type‐2 diabetes.
Neuroprotective Benefit:
MOTS-c may have anti-inflammatory properties and promote cellular energetics but is not BBB penetrant.
Ageing and related health concerns:
MOTS-c enhances metabolic flexibility, improves insulin sensitivity, and may act as an exercise mimetic. MOTS-c rejuvenates ageing phenotypes in muscle and may impact longevity. MOTS-c is hypothesized to be involved in the longevity of the Japanese. The polymorphism located in the MOTS‐c encoding mtDNA, m.1382A>C, causes a Lys14Gln replacement in MOTS-c, and is predicted to have a functional effect. This polymorphism is specific to the Northeast Asian population and is
part of the haplogroup D4b2, which is associated with exceptional longevity.
Mice treated with MOTS-c (15 mg/kg 3x/week) starting in old age (23.5 months) showed a trend toward
increased lifespan. They had a 6.4% increase in median lifespan (970 vs 912 days), and a 7% increase
in maximum lifespan (1120 vs 1047 days) (Hazard ratio 0.654, P=0.05). Additional research is needed to confirm these results and determine if earlier intervention has a stronger effect.
MOTS-c and Osteoporsis:
MOTS-c appears to be functional in type I collagen synthesis by osteoblasts in bone. Studies closely observing osteoblast cells, suggest that MOTS-c may influence the TGF-beta/SMAD pathway that controls the health and survival of osteoblasts. Osteoblasts improve osteoblast survival, thereby bettering the synthesis of type I collagen and its strength and integrity. According to scientific studies, MOTS-c may benefit afflictions like osteoporosis by possible bone marrow enhancement and stem cell differentiation via the action of the TGF-beta/SMAD pathway. According to these studies, this may result in enhanced osteogenesis, including the enhancement of osteoblast survival and stem cell development.
Structure
Che N, Qiu W, Wang JK, Sun XX, Xu LX, Liu R, Gu L. MOTS-c improves osteoporosis by promoting the synthesis of type I collagen in osteoblasts via TGF-β/SMAD signaling pathway. Eur Rev Med Pharmacol Sci. 2019 Apr;23(8):3183-3189. doi: 10.26355/eurrev_201904_17676. PMID: 31081069.
Hu BT, Chen WZ. MOTS-c improves osteoporosis by promoting osteogenic differentiation of bone marrow mesenchymal stem cells via TGF-β/Smad pathway. Eur Rev Med Pharmacol Sci. 2018 Nov;22(21):7156-7163. doi: 10.26355/eurrev_201811_16247. PMID: 30468456.
Lu H, Wei M, Zhai Y, Li Q, Ye Z, Wang L, Luo W, Chen J, Lu Z. MOTS-c peptide regulates adipose homeostasis to prevent ovariectomy-induced metabolic dysfunction. J Mol Med (Berl). 2019 Apr;97(4):473-485. doi: 10.1007/s00109-018-01738-w. Epub 2019 Feb 6. PMID: 30725119.
Kim KH, Son JM, Benayoun BA, Lee C. The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress. Cell Metab. 2018 Sep 4;28(3):516-524.e7. doi: 10.1016/j.cmet.2018.06.008. Epub 2018 Jul 5. PMID: 29983246; PMCID: PMC6185997.
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Products shown on this website are prepared for RESEARCH USE ONLY and may not be used for other purposes.
