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PT-141, also called Bremelanotide, is a synthetic peptide composed of seven amino acids. Pt-141 is a synthetic derivative of alpha-melanocyte-stimulating hormone.
It has been tested as a treatment for both male/female hypoactive sexual desire disorder and acute haemorrhage. When test animals were presented with the isolated hormone, it was reported to present elevated reproductive functions. Research shows that it promotes sexual arousal and stimulates the immune system, which is one of the primary areas of research currently being conducted.
PT-141 peptide has been shown to:
Improve erectile dysfunction
Enhanced mood
Increase in libido levels
Low blood pressure
Reduced stress levels
Increased metabolism
Improved skin elasticity
This product is prepared for RESEARCH USE ONLY and may not be used for other purposes.
PT-141, is a peptide composed of seven amino acids. PT-141 appears to be agonistic to melanocortin receptors, which is similar to the natural hormone alpha-MSH. It was derived from the Melanotan 2 peptide. Known as Bremelanotide, PT-141 has been discovered to help treat sexual disorders such as erectile dysfunction or hypoactive sexual desire disorder. PT-141 works for both men and women to improve sexual function.
PT-141 works directly through the nervous system to increase arousal, desire, and satisfaction with sex. Treatments like Viagra and Cialis work through the blood flow and only give you the ability to achieve an erection. However, PT-141 gives you the desire and motivation along with the ability to achieve an erection.
Animal studies on PT-141 have aimed to understand the potential of the peptide in the central nervous system and possibly also some brain regions. One study on rats apparently resulted in increased appetitive behaviour of solicitation without impacting the sexual pace.
When PT-141 was introduced peripherally, it appeared to activate the mPOA and other hypothalamic and limbic brain regions possibly associated with sexual behaviour. The study hypothesizes that PT-141 might function by potentially activating dopamine terminals located in the mPOA, but further research is needed to confirm this. The researchers commented that the peptide appears to possess the potential to influence sexual function.
Structure
Ac-Nle-c[Asp-His-DPhe-Arg-Trp-Lys]-NH2 induces penile erection via brain and spinal melanocortin receptors H Wessells 1, V J Hruby, J Hackett, G Han, P Balse-Srinivasan, T W Vanderah Affiliations expand
PMID: 12710982 DOI: 10.1016/s0306-4522(02)00866-7
Bremelanotide for female sexual dysfunctions in premenopausal women: a randomized, placebo-controlled dose-finding trial
Anita H Clayton 1, Stanley E Althof 2, Sheryl Kingsberg 3, Leonard R DeRogatis 4, Robin Kroll 5, Irwin Goldstein 6, Jed Kaminetsky 7, Carl Spana 8, Johna Lucas 8, Robert Jordan 8, David J Portman 9
Reduction in corpora lutea number in obese melanocortin-4-receptor-deficient mice Mara Sandrock,1 Angela Schulz,2 Claudia Merkwitz,1 Torsten Schöneberg,2 Katharina Spanel-Borowski,1 and Albert Rickencorresponding author1
Melanotan II, a melanocortin agonist, partially rescues the impaired thermogenic capacity of pituitary adenylate cyclase-activating polypeptide deficient mice
Thecla Rae McMillan 1, Maeghan A M Forster 1, Landon I Short 1, Alexander P Rudecki 1, Daemon L Cline 1, Sarah L Gray 1
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Products shown on this website are prepared for RESEARCH USE ONLY and may not be used for other purposes.
