TB-500 (thymosin-beta-4)

What is TB-500?

TB-500 is a synthetic peptide based on a fragment of Thymosin Beta-4, a naturally occurring protein involved in tissue repair. In research it is studied for its systemic, body-wide effect on recovery — a contrast to the localised action of BPC-157.

What is TB-500 researched for?

In preclinical animal studies, TB-500 has been investigated for:

• Cell migration — helping repair cells move to where they are needed (Goldstein; Malinda)
• Muscle and soft-tissue regeneration — across multiple tissue types at once
• Angiogenesis — the formation of new blood vessels
• Inflammation — reducing systemic inflammation
• Flexibility and connective tissue

What is the difference between TB-500 and Thymosin Beta-4?

Thymosin Beta-4 is the full naturally occurring protein; TB-500 is a shorter synthetic fragment that carries the active region responsible for much of the tissue-repair and cell-migration activity studied in research. The two names are often used interchangeably, but they are not identical.

How does TB-500 work?

TB-500’s active fragment binds actin, a protein central to cell structure and movement. In research this is linked to improved cell migration, new blood-vessel formation and tissue regeneration throughout the body, rather than at a single site.

Research summary

Further reading: Why TB-500 and BPC-157 shouldn’t be pre-mixed