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-21%BPC-157, also known as Body Protection Compound 157, is a synthetic peptide derived from a protein found in the human gastric system. Extensively studied in preclinical models, BPC-157 peptide has shown promising results in accelerating tissue repair, promoting wound healing, and supporting gastrointestinal health.
Research indicates that BPC-157 can support the regeneration of:
Its systemic effects may contribute to faster recovery from injuries, particularly those affecting connective tissue and soft tissue.
BPC-157 Benefits
BPC-157 has been shown to:
This product is prepared for RESEARCH USE ONLY and may not be used for other purposes.
BPC-157 is a peptide composed of 15 amino acids that has been shown to have several regenerative properties in animal models. BPC-157 is naturally occurring in gastric juice, but can also be synthesized in the laboratory.
BPC-157 was first identified in 1993 by a team of researchers in Croatia investigating stomach tissue’s regenerative properties. They found that when BPC-157 was injected into rats with damaged muscle tissue, it promoted muscle regeneration and enhanced the healing process. Since then, BPC-157 has been the subject of numerous studies investigating its therapeutic potential for a wide range of conditions.
As such, it has the potential to be used to treat a range of conditions that involve tissue damage and inflammation.
BPC-157 has attracted a lot of interest from those investigating the treatment of gastrointestinal conditions like Crohn’s disease, ulcerative colitis, and collagenous colitis, dental afflictions like periodontitis, as well as internal and superficial wounds in animal testing.
Fibroblast Recruitment for Enhanced Healing
BPC-157 stimulates the rapid migration of fibroblasts to the site of damage; these cells play an integral role in providing proteinaceous extracellular matrix material for tissue repair. BPC-157 has been shown to induce the production of F-actin in recruited fibroblasts, which is one of the materials necessary to begin rebuilding the site of tissue damage. BPC-157 also assists in the healing of wounds and viscera by increasing the probability of cellular survival under oxidative stress, which is common at the site of traumatic injury. If fewer cells have died at the site of damage, then more cells can be activated in order to begin repair.
Molecular Weight
1419.5 g/mol
Computed by PubChem 2.1 (PubChem release 2021.05.07)
Dates
2005-08-08
2023-09-16
Structure
Sikiric, P., Seiwerth, S., Grabarevic, Z., Petek, M., Rucman, R., Turkovic, B., & Brkic, T. (1994). The beneficial effect of BPC 157, a 15 amino acid peptide BPC fragment, on gastric and duodenal lesions induced by restraint stress, cysteamine and 96% ethanol in rats. A comparative study with H 2 receptor antagonists, dopamine promotors and gut peptides.Life sciences,54(5), PL63-PL68.
https://pubmed.ncbi.nlm.nih.gov/25995620/
Seiwerth, S., Sikiric, P., Grabarevic, Z., Zoricic, I., Hanzevacki, M., Ljubanovic, D., … & Kolega, Z. (1997). BPC 157’s effect on healing. Journal of Physiology-Paris,91(3), 173-178.
Sikirić, P., Seiwerth, S., Grabarević, Ž., Ručman, R., Petek, M., Jagić, V., … & Marović, A. (1996). Beneficial effect of a novel pentadecapeptide BPC 157 on gastric lesions induced by restraint stress, ethanol, indomethacin, and capsaicin neurotoxicity. Digestive diseases and sciences,41(8), 1604-1614. }
Keremi, B., Lohinai, Z., Komora, P., Duhaj, S., Borsi, K., Jobbagy-Ovari, G., & Varga, G. (2009). Antiinflammatory effect of BPC 157 on experimental periodontitis in rats. J Physiol Pharmacol,60(Suppl 7), 115-22.
Brcic, L., Brcic, I., Staresinic, M., Novinscak, T., Sikiric, P., & Seiwerth, S. (2009). Modulatory effect of gastric pentadecapeptide BPC 157 on angiogenesis in muscle and tendon healing. J Physiol Pharmacol,60(Suppl 7), 191-96.
Krivic, A., Majerovic, M., Jelic, I., Seiwerth, S., & Sikiric, P. (2008). Modulation of early functional recovery of Achilles tendon to bone unit after transection by BPC 157 and methylprednisolone. Inflammation Research,57(5), 205-210.
Chang, C. H., Tsai, W. C., Lin, M. S., Hsu, Y. H., & Pang, J. H. S. (2011). The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. Journal of Applied Physiology,110(3), 774-780.
Sikiric, P., Marovic, A., Matoz, W., Anic, T., Buljat, G., Mikus, D., … & Hahn, V. (1999). A behavioural study of the effect of pentadecapeptide BPC 157 in Parkinson’s disease models in mice and gastric lesions induced by 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine. Journal of Physiology-Paris,93(6), 505-512.
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Products shown on this website are prepared for RESEARCH USE ONLY and may not be used for other purposes.
