TB-500 (thymosin-beta-4)

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TB-500 (thymosin-beta-4)

TB-500 (Thymosin Beta-4) — 5mg research peptide

One of the most widely studied peptides in tissue-repair and recovery research. In preclinical studies, TB-500 has been investigated for how it supports new blood vessel growth, cell repair and recovery.

  • ✓ ≥99% purity, HPLC verified
  • ✓ Lyophilised powder, ready to reconstitute
  • ✓ Dispatched fast from the UK
concentration: 5mg

Original price was: £34.99.Current price is: £26.99.

-23%
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Free 10ml Bacteriostatic Water

What Is TB-500 (Thymosin Beta-4)?

TB-500 is a synthetic form of Thymosin Beta-4, a peptide that occurs naturally in the body and is made up of 43 amino acids. Its main job is to bind to actin — one of the key building-block proteins inside cells — which helps control how cells move, grow and repair themselves. That role makes it one of the most widely studied peptides in tissue-repair and blood-vessel research.

Buy TB-500 UK for Preclinical Research

In animal studies, Thymosin Beta-4 has been researched for how it supports the growth of new blood vessels, helps cells migrate to where they’re needed, and influences the body’s response to inflammation and stress at a cellular level. It’s a popular reference compound for scientists studying recovery, repair and regeneration.

What Researchers Study TB-500 For

In preclinical animal studies, Thymosin Beta-4 has been investigated for:

  • How new blood vessels form and repair (angiogenesis)
  • Wound healing and soft-tissue recovery
  • Calming inflammation and oxidative stress
  • How cells move, rebuild and organise themselves
  • Heart tissue repair after injury
  • Muscle recovery and regeneration

TB-500 is often studied alongside BPC-157 in recovery and tissue-repair research, and the two are commonly investigated together in the BPC-157 & TB-500 research blend. Reconstitution for research use requires bacteriostatic water and syringes, also available as bacteriostatic water on its own.

Specifications

≥99% purity, HPLC verified. Supplied as a lyophilised powder. Dispatched from the UK.

These products are supplied strictly for laboratory research and development purposes only. Not intended for human or animal consumption, diagnosis, treatment, or prevention of any disease.

Thymosin Beta-4 in Published Research

TB-500 is the synthetic form of Thymosin Beta-4, a peptide found naturally in most mammalian tissue. Because it binds to actin and helps regulate how cells move and organise themselves, it has become a widely used reference compound in laboratory studies of tissue repair and blood-vessel formation.

In preclinical animal models, researchers have studied Thymosin Beta-4 for its role in encouraging the growth of new blood vessels (angiogenesis), supporting cell migration, and influencing how tissue responds to inflammation and oxidative stress. Published work has examined these mechanisms in models of skin, connective tissue, cardiac and skeletal muscle research.

Its actin-binding activity is one of the most studied aspects of the peptide, and it is frequently used in regeneration and remodelling research alongside related compounds such as BPC-157.

For the full list of peer-reviewed references behind these research areas, see the Sources tab.

Molecular Formula: C212H350N56O78S
Molecular Weight: 4963.4 g/mol
View on PubChem

Structure

Synonyms
Thymosin Beta 4
77591-33-4
THYMOSIN BETA 4 ACETATE

([13C6]Leu17)-Thymosin b4 (human, bovine, horse, rat) trifluoroacetate salt Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-[13C6]Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser-OH trifluoroacetate salt
Thymosin b4 (cattle)

Selected Research References

  1. Goldstein AL, Hannappel E, Kleinman HK. Thymosin β4: actin-sequestering protein moonlights to repair injured tissues. Trends Mol Med. — PubMed
  2. Philp D, et al. The actin binding site on thymosin beta4 promotes angiogenesis. FASEB J. 2003. — PubMed
  3. Malinda KM, et al. Thymosin beta4 promotes angiogenesis, wound healing, and hair follicle development.PubMed
  4. Kleinman HK, Sosne G. Thymosin β4 Promotes Dermal Healing. 2016. — PubMed
  5. Smart N, et al. Thymosin beta4 and angiogenesis: modes of action and therapeutic potential. Angiogenesis. 2007. — PubMed
  6. Tokura Y, et al. Muscle injury-induced thymosin β4 acts as a chemoattractant for myoblasts. 2011. — PubMed
  7. Song Z, Han A, Hu B. Thymosin β4 promotes zebrafish Mauthner axon regeneration via actin polymerisation. BMC Biol. 2024. — PubMed
  8. Maar K, et al. Thymosin Beta-4 Modulates Cardiac Remodelling by Regulating ROCK1 Expression in Adult Mammals. Int J Mol Sci. 2025. — PubMed
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